Alpha Heavy Chain Disease Post-Diffuse Large B-cell Lymphoma Remission: A Series of Two Cases

Abstract Introduction/Objective Heavy chain disease is the production of abnormal monoclonal immunoglobulin heavy chains. Alpha typically identified in mucosa-associated lymphoid tissue lymphomas and secreted due to chronic infection. The alpha can manifest as hypogammaglobulinemia or a normal serum protein electrophoresis (SPEP). Broadband may appear alpha-2 beta mobility regions. Methods/Case Report We describe two cases which was detected 60-year-old female with diffuse large B-cell lymphoma (DLBCL) thoracic spine 71-year-old mediastinal DLBCL. Both patients achieved clinical radiological remission. Results (if Case Study enter NA) A distinct IgA band without an associated light on first patient's immunofixation essay (SIFE) one year later. For second case, there distortion beta-2 region, elevated kappa free (230.6 mg/dL), lambda ratio 14.23, suggesting possible gammopathy unknown significance. Interestingly, even IgA, remained symptom-free, any gastrointestinal manifestations, concurrent PET scans show no recurrence. Conclusion To best our knowledge, these are describing presence association significance secretion history DLBCL needs be further assessed we need identify non-clonally related paraprotein post-treatment for